Our Projects

Our Projects

Penn ISC3 uses behavioral economics and implementation science to improve cancer care. The center leads several projects across Penn Medicine.


Tobacco Cessation

Project Leads: Frank Leone, Brian Jenssen

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Tobacco use limits the effectiveness of cancer treatment, so our first signature project focuses on helping people stop using tobacco. This project tests behavioral economics-informed multilevel implementation strategies to increase Tobacco Use Treatment Service (TUTS) referral and engagement. It aims to conduct a 4-arm pragmatic cluster randomized clinical trial (RCT) to test the effectiveness of nudges to clinicians, nudges to patients, or nudges to both to increase TUTS referral and to conduct a quantitative evaluation to identify moderators of implementation effects on TUTS referral.

You can read the study protocol for this project here.


Serious Illness Conversations

Project Leads: Samuel Takvorian, Ravi Parikh

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Serious illness conversations (SICs) are an evidence-based approach to eliciting patients’ values, goals, and care preferences that improve patient outcomes, but they are not widely used. The SIC project tests behavioral economics-informed multilevel implementation strategies to increase SIC frequency and timeliness. It aims to conduct a 4-arm pragmatic cluster RCT to test the effectiveness of nudges to clinicians, nudges to patients, or nudges to both in increasing the frequency and timeliness of SIC documentation and to conduct a quantitative evaluation using secondary data to identify moderators of implementation effects on SIC rates.

You can read the study protocol for this project here.


Breast MRI Screening

Project Lead: Anne Marie McCarthy

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Women with dense breasts have 3-5 fold increased risk for breast cancer as women without dense breasts. Dense breast tissue can “mask” small tumors, leading to reduced mammography sensitivity. Recent randomized controlled trials demonstrate that supplemental breast MRI screening improves detection of small, invasive cancers that are not detected by mammography. This project proposes a multilevel randomized 2×2 factorial pilot trial to determine whether electronic health record (EHR) nudges increase utilization of supplemental breast MRI screening among eligible women with extremely dense breasts.


Patient-Reported Outcomes

Project Leads: Samuel Takvorian, Ravi Parikh

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Routine monitoring of patient-reported outcomes (PROs) for patients with advanced solid malignancies is an evidence-based practice that improves symptoms and quality of life, reduces unplanned acute care, and extends overall survival. Still, there is variation in adoption of and adherence to routine PRO monitoring, owing to multilevel barriers to implementation and concerns among clinicians regarding the utility of PROs in actual practice. This study will identify the extent to which clinician- and patient-directed implementation strategies affect patient adherence to PRO monitoring. These outcomes will inform future health system strategies to promote PRO adherence and thereby improve outcomes equitably for patients with cancer.


Increasing Genetic Testing for Breast and Ovarian Cancer Predisposition

Project Leads: Susan Domchek, Katherine Nathanson

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Germline genetic testing is recommended by National Cancer Center Network (NCCN) in individuals with a personal history of ovarian cancer, young-onset (<45 years) breast cancer, and a family history of ovarian cancer or male breast cancer, among others. Recent publications demonstrate that the uptake of genetic testing is under-utilized, and rates consistently lower, in minority populations. The use of EHR-based algorithms to identify patients for whom genetic testing is recommended based on NCCN guidelines, particularly those without a family history, is cutting edge.


From the Acceleration Lab

Methods Project 1 – Rapid Cycle Approaches

Project Leads: Alison Buttenheim, David Asch

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The rapid-cycle approaches project supports the signature projects in applying insights from innovation methods drawn from industries outside of healthcare to accelerate the pace of learning. It aims to apply rapid-cycle approaches within the signature projects to optimize implementation strategy design and feasibility.


Methods Project 2 – Contextual Inquiry

Project Leads: Kate Rendle, Rinad Beidas

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This project uses mixed methods approaches to develop an empirical basis for understanding and overcoming barriers and facilitators to implementation across projects. It aims to apply the Consolidated Framework for Implementation Research (CFIR) to capture and describe multilevel factors across and within signature projects and conduct Qualitative Comparative Analysis (QCA) to identify necessary and sufficient conditions for implementation. It also aims to and collect data on baseline inner setting via quantitative surveys and post-implementation mixed-methods data via surveys and semi-structured interviews.


Methods Project 3 & NCI Supplement – Health Equity

Project Leads: Lola Fayanju, Kate Rendle, Rachel Shelton, Krisda Chaiyachati

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This project ensures that all signature projects have a focus on identifying and documenting cancer-related health disparities and uses implementation science measures, methods, strategies, and frameworks to more explicitly center health equity. It aims to identify and understand existing health disparities prior to initiating each signature project. It also aims to engage in contextual inquiry, using mixed-methods research and purposeful sampling of populations experiencing inequities to understand how the implementation strategies are received by individuals who experience health disparities as well as a more in-depth understanding of factors that shape these inequities. Building on the wider health equity methods project, the National Cancer Institute awarded Penn ISC3 with an additional health equity-focused supplemental grant. This supplement will focus on how social determinants of health (SDOH), social needs, and social risks impact the implementation of evidence-based cancer care and health equity.

You can read more about the team’s work in health equity here.